Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.66 |
| ▸ | AXL | P30530 | 8/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.66 |
| ▸ | MERTK | Q12866 | 3/20 | 0.60 |
| ▸ | MET | P08581 | 4/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5638280 | 0.91 | KDR (0.78) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL28432905 | 0.89 | KDR (0.68) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1896412 | 0.87 | KDR (0.67) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1893938 | 0.86 | KDR (0.70) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1890694 | 0.86 | PDGFRA (0.61) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1895952 | 0.85 | KDR (0.69) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1896921 | 0.84 | KDR (0.82) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1899318 | 0.83 | PDGFRA (0.62) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1249688 | 0.83 | KDR (0.66) | KDRAXLPDGFRAFGFR2KIT | |
| SCHEMBL1895265 | 0.83 | KDR (0.66) | KDRAXLPDGFRAFGFR2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1777218-A1 | Process for the preparation of 4-phenoxy quinoline derivatives | Eisai R&D Management Co., Ltd. (JP) | 2007-04-25 | — | — | EP | disclosed |