Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.67 |
| ▸ | CDK2 | P24941 | 10/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885032 | 0.86 | GSK3B (0.79) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL13305408 | 0.85 | GSK3B (0.74) | GSK3BCDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL11931128 | 0.84 | CDK2 (0.64) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13116761 | 0.83 | GSK3B (0.77) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13308740 | 0.81 | GSK3B (0.76) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13146282 | 0.80 | GSK3B (0.73) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12954166 | 0.80 | GSK3B (0.78) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13118443 | 0.80 | GSK3B (0.78) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13116963 | 0.80 | GSK3B (0.74) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953281 | 0.79 | GSK3B (0.72) | GSK3BCDK2CCNA2CCNA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |