Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845498 | 0.86 | CHEK1 (0.78) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218607 | 0.86 | CHEK1 (0.53) | CHEK1 | |
| SCHEMBL11931602 | 0.78 | CHEK1 (0.69) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931586 | 0.76 | CHEK1 (0.65) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931089 | 0.76 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218632 | 0.72 | CHEK1 (0.45) | CHEK1 | |
| SCHEMBL14232209 | 0.71 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218885 | 0.71 | CHEK1 (0.65) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14232210 | 0.70 | CHEK1 (0.75) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218630 | 0.70 | PIK3CA (0.41) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |