Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930781 | 0.88 | HRH4 (0.57) | CHEK1CCNA2CDK2CCNA1HRH4 | |
| SCHEMBL14545799 | 0.82 | CHEK1 (0.51) | CHEK1CCNA2CDK2CCNA1SMPD3 | |
| SCHEMBL14050800 | 0.77 | PDE10A (0.47) | PDE10A | |
| SCHEMBL11930795 | 0.74 | PDE10A (0.40) | CHEK1CCNA2CDK2CCNA1HRH4 | |
| SCHEMBL15184400 | 0.72 | SMPD3 (0.45) | SMPD3HRH4HRH3KDM4ENPC1 | |
| SCHEMBL15393808 | 0.72 | HRH4 (0.51) | SMPD3HRH4HRH3TYK2 | |
| SCHEMBL15393799 | 0.72 | HRH4 (0.51) | SMPD3HRH4HRH3TYK2 | |
| SCHEMBL23152050 | 0.71 | CDK2 (0.58) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL30886761 | 0.71 | CDK2 (0.46) | CHEK1CCNA2CDK2CCNA1SMPD3 | |
| SCHEMBL14516590 | 0.71 | HRH4 (0.51) | SMPD3HRH4HRH3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |