Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 18/20 | 0.56 |
| ▸ | CDK2 | P24941 | 18/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 18/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | LATS1 | O95835 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.56 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | PSMC4 | P43686 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.56 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14539523 | 0.89 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539538 | 0.88 | CHEK1 (0.43) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539518 | 0.88 | CHEK1 (0.45) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539527 | 0.87 | CHEK1 (0.58) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539522 | 0.87 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539640 | 0.85 | CHEK1 (0.60) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539525 | 0.85 | CHEK1 (0.66) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539539 | 0.85 | CHEK1 (0.60) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539509 | 0.85 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539528 | 0.83 | CHEK1 (0.62) | CHEK1CCNA2CDK2CCNA1RPS6KA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |