Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14418661 | 0.90 | GSK3B (0.54) | GSK3BCHEK1MAPK1HTTCCNE1 | |
| SCHEMBL13146324 | 0.83 | GSK3B (0.77) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13289230 | 0.83 | GSK3B (0.52) | GSK3BCHEK1MAPK1HTT | |
| SCHEMBL13288814 | 0.81 | GSK3B (0.61) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13304869 | 0.80 | GSK3B (0.77) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL12953848 | 0.80 | GSK3B (0.61) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14545281 | 0.80 | GSK3B (0.50) | GSK3BCHEK1MAPK1HTT | |
| SCHEMBL14613495 | 0.79 | GSK3B (0.51) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13146320 | 0.79 | GSK3B (0.68) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14581374 | 0.78 | GSK3B (0.69) | GSK3BCHEK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |