Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 3/20 | 0.42 |
| ▸ | ACACA | Q13085 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405140 | 0.88 | HTR2C (0.52) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3401746 | 0.85 | HTR2C (0.75) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3405777 | 0.83 | HTR2C (0.50) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3400921 | 0.81 | CNR1 (0.66) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL13309952 | 0.81 | HTR2C (0.60) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3405797 | 0.81 | CNR1 (0.52) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3404938 | 0.81 | HTR2C (0.48) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3405829 | 0.80 | HTR2C (0.57) | HTR2CLMNASMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL3403306 | 0.80 | HTR2C (0.56) | HTR2CLMNACNR1ACACBACACA | |
| SCHEMBL3406034 | 0.80 | HTR2C (0.56) | HTR2CLMNACNR1ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |