Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.54 |
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GPR39 | O43194 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120681 | 0.91 | CDK2 (0.67) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13289053 | 0.91 | CDK2 (0.53) | CDK2GSK3BPOLBCCNA2CCNA1 | |
| SCHEMBL13120634 | 0.87 | CDK2 (0.62) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13120668 | 0.86 | CDK2 (0.67) | CDK2GSK3BCCNA2CCNA1CYP1A2 | |
| SCHEMBL13289052 | 0.86 | CDK2 (0.53) | CDK2GSK3BPOLBCCNA2CCNA1 | |
| SCHEMBL13120687 | 0.84 | CDK2 (0.69) | CDK2GSK3BPOLBCCNA2CCNA1 | |
| SCHEMBL14545999 | 0.83 | CDK2 (0.54) | CDK2GSK3BPOLBCCNA2CCNA1 | |
| SCHEMBL13120696 | 0.83 | CDK2 (0.65) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13120719 | 0.83 | CDK2 (0.65) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13120674 | 0.82 | CDK2 (0.67) | CDK2GSK3BCCNA2CCNA1GPR39 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |