Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 11/20 | 0.52 |
| ▸ | BTK | Q06187 | 10/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12085327 | 0.90 | PAK4 (0.56) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL13048678 | 0.86 | HTR2A (0.52) | JAK3BTKMEN1THRBRAB9A | |
| SCHEMBL12085425 | 0.85 | MERTK (0.66) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL14547840 | 0.84 | PAK4 (0.54) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL12085429 | 0.84 | PTK2 (0.64) | PAK4JAK3BTKIRAK4MERTK | |
| SCHEMBL14547888 | 0.84 | SYK (0.62) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL14547896 | 0.84 | JAK3 (0.67) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL12085376 | 0.83 | JAK3 (0.61) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL14547954 | 0.83 | PTK2 (0.60) | PAK4JAK3BTKIRAK4LRRK2 | |
| SCHEMBL14547927 | 0.82 | JAK3 (0.55) | PAK4JAK3BTKIRAK4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |