Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 4/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | LTK | P29376 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547697 | 0.82 | PAK4 (0.51) | PTK2TTKPAK4MAPK8JAK3 | |
| SCHEMBL3283548 | 0.80 | LRRK2 (0.57) | CYP1A2GRM4JAK2BRD4PTK2 | |
| SCHEMBL3280599 | 0.79 | PTK2 (0.57) | JAK2BRD4PTK2TTKJAK3 | |
| SCHEMBL12085487 | 0.78 | CDC7 (0.46) | JAK2SYKDAPK3MAP4K4PAK4 | |
| SCHEMBL3279212 | 0.75 | BRD4 (0.53) | JAK2BRD4PTK2CREBBPTTK | |
| SCHEMBL13994048 | 0.75 | CYP1A2 (0.45) | CYP1A2GRM4SLC2A1BRD4CREBBP | |
| SCHEMBL14547763 | 0.72 | JAK2 (0.45) | JAK2BRD4PTK2LRRK2TTK | |
| SCHEMBL14547768 | 0.72 | TOP2A (0.67) | LRRK2SYKCSF1RKDRJAK3 | |
| SCHEMBL3283442 | 0.72 | LRRK2 (0.55) | JAK2BRD4PTK2LRRK2CREBBP | |
| SCHEMBL14287388 | 0.71 | LRRK2 (0.68) | JAK2PTK2LRRK2TTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |