Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.77 |
| ▸ | RET | P07949 | 10/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.64 |
| ▸ | AURKA | O14965 | 3/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.64 |
| ▸ | PAK4 | O96013 | 3/20 | 0.64 |
| ▸ | LTK | P29376 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.64 |
| ▸ | CLK2 | P49760 | 3/20 | 0.64 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.64 |
| ▸ | JAK3 | P52333 | 3/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.64 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.64 |
| ▸ | MST1R | Q04912 | 3/20 | 0.64 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547778 | 0.91 | LRRK2 (0.72) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14547955 | 0.88 | LRRK2 (0.68) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14287413 | 0.87 | LRRK2 (1.00) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14547939 | 0.84 | RET (0.77) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14287407 | 0.84 | LRRK2 (0.82) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14547935 | 0.83 | LRRK2 (0.74) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14547975 | 0.83 | LRRK2 (0.80) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14547972 | 0.83 | LRRK2 (0.74) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14547958 | 0.82 | LRRK2 (0.72) | LRRK2RETPTK2AURKADAPK3 | |
| SCHEMBL14287418 | 0.82 | PTK2 (0.83) | LRRK2RETPTK2AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |