Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.56 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | TTK | P33981 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | MST1 | P26927 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547733 | 0.92 | LRRK2 (0.59) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547960 | 0.91 | LRRK2 (0.58) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547950 | 0.82 | LRRK2 (0.50) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547735 | 0.81 | LRRK2 (0.58) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547864 | 0.79 | LRRK2 (0.62) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547958 | 0.78 | LRRK2 (0.72) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547935 | 0.77 | LRRK2 (0.74) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547919 | 0.76 | LRRK2 (0.70) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547861 | 0.76 | LRRK2 (0.64) | LRRK2IGF1RTTKJAK3JAK2 | |
| SCHEMBL14547952 | 0.76 | LRRK2 (0.61) | LRRK2IGF1RTTKJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |