Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.59 |
| ▸ | SYK | P43405 | 8/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.56 |
| ▸ | PAK4 | O96013 | 7/20 | 0.56 |
| ▸ | JAK2 | O60674 | 7/20 | 0.56 |
| ▸ | RET | P07949 | 6/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.56 |
| ▸ | LTK | P29376 | 5/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.56 |
| ▸ | ABL1 | P00519 | 5/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.56 |
| ▸ | LCK | P06239 | 4/20 | 0.56 |
| ▸ | FYN | P06241 | 4/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.56 |
| ▸ | AURKA | O14965 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547766 | 0.93 | LRRK2 (0.58) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547941 | 0.83 | LRRK2 (0.59) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547931 | 0.80 | LRRK2 (0.58) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547949 | 0.80 | LRRK2 (0.60) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547956 | 0.80 | LRRK2 (0.63) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547958 | 0.80 | LRRK2 (0.72) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547913 | 0.80 | LRRK2 (0.57) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547772 | 0.80 | LRRK2 (0.57) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547730 | 0.79 | LRRK2 (0.62) | LRRK2SYKPTK2PAK4JAK2 | |
| SCHEMBL14547935 | 0.79 | LRRK2 (0.74) | LRRK2SYKPTK2PAK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |