Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976550 | 0.90 | EGFR (0.64) | EGFRERBB2ERBB4MEN1PIK3C2B | |
| SCHEMBL14548629 | 0.90 | EGFR (0.53) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL14548700 | 0.87 | EGFR (0.56) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL14548701 | 0.87 | EGFR (0.55) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL14548601 | 0.84 | EGFR (0.66) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL14548703 | 0.82 | EGFR (0.50) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL6959611 | 0.82 | EGFR (0.60) | EGFRERBB2ERBB4MEN1PIK3C2B | |
| SCHEMBL14548602 | 0.82 | EGFR (0.60) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL9975239 | 0.81 | ERBB2 (0.55) | EGFRERBB2ERBB4ABL1INSR | |
| SCHEMBL6980092 | 0.80 | EGFR (0.67) | EGFRERBB2ERBB4ABL1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349857-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2013-01-08 | — | — | US | disclosed |