Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | MERTK | Q12866 | 1/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | TXK | P42681 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881676 | 0.85 | KDR (0.53) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL14024540 | 0.83 | KDR (0.73) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL14024352 | 0.72 | TNNI3K (0.53) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL14024423 | 0.71 | JAK3 (0.49) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL14024420 | 0.71 | JAK3 (0.53) | FLT1TNNI3KSYKCDK2CDK4 | |
| SCHEMBL4881985 | 0.70 | EPHB4 (0.59) | KDRFLT1FGFR1FLT3NTRK2 | |
| SCHEMBL14024541 | 0.69 | KDR (0.57) | KDRFLT1FGFR1FLT4FLT3 | |
| Surufatinib SCHEMBL1822601 | 0.69 | KDR (1.00) | KDRFLT1FGFR1FLT4FLT3 | |
| Surufatinib SCHEMBL29363337 | 0.69 | KDR (1.00) | KDRFLT1FGFR1FLT4FLT3 | |
| Surufatinib SCHEMBL29366533 | 0.69 | KDR (1.00) | KDRFLT1FGFR1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349859-B2 | Pyrimidine derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2013-01-08 | — | — | US | disclosed |