Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372093 | 0.79 | CYP19A1 (0.59) | CYP19A1CYP11B1CYP11B2ALDH1A1POLB | |
| SCHEMBL28174118 | 0.77 | CYP19A1 (0.60) | CYP19A1CYP11B1CYP11B2ALDH1A1POLB | |
| SCHEMBL13946675 | 0.77 | CYP19A1 (0.60) | CYP19A1CYP11B1CYP11B2ALDH1A1POLB | |
| SCHEMBL14322800 | 0.77 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2ALDH1A1CYP3A4 | |
| SCHEMBL1535118 | 0.76 | CYP19A1 (0.57) | CYP19A1CYP11B1CYP11B2CYP1A2POLB | |
| SCHEMBL6323414 | 0.75 | CYP19A1 (0.79) | CYP19A1CYP11B1CYP11B2CYP1A2POLB | |
| SCHEMBL28061897 | 0.74 | HDAC1 (0.53) | CYP19A1ESR1ESR2CYP11B1CYP11B2 | |
| Bromide SCHEMBL10849755 | 0.74 | CYP19A1 (0.77) | CYP19A1CYP11B1CYP11B2CYP1A2POLB | |
| SCHEMBL2222933 | 0.73 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2CYP1A2POLB | |
| SCHEMBL2286797 | 0.72 | CYP11B1 (0.64) | CYP19A1CYP11B1CYP11B2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912972-A1 | SOCE INHIBITORS AND THERAPEUTIC USES THEREOF | Centre Hospitalier Régional et Universitaire de Brest (FR) | 2021-11-24 | — | — | EP | disclosed |
| EP-1446388-B1 | 1,2,4-TRIAZOLE DERIVATIVES CONTAINING A SULPHAMATE GROUP AS AROMATASE INHIBITORS | STERIX LTD (GB) | 2013-01-09 | — | — | EP | disclosed |