Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222807 | 0.90 | KDM4E (0.55) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221741 | 0.84 | KDM4E (0.57) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2224188 | 0.82 | NPC1 (0.56) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222555 | 0.81 | MAPT (0.56) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222272 | 0.80 | MAPT (0.53) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2224139 | 0.79 | KDM4E (0.55) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2223350 | 0.79 | KDM4E (0.55) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2224197 | 0.79 | MAPT (0.62) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2225486 | 0.79 | KDM4E (0.54) | KDM4EMAPTPOLBNPSR1L3MBTL1 | |
| SCHEMBL2225364 | 0.79 | MAPT (0.52) | KDM4EMAPTPOLBNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013006596-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |