Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 5/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21682962 | 0.86 | CDK5 (0.71) | CDK5CDK5R1LMNAMAPK1MAPT | |
| SCHEMBL5341105 | 0.82 | CDK5 (0.81) | CDK5CDK5R1LMNAMAPK1MAPT | |
| SCHEMBL14558320 | 0.82 | CDK5 (0.67) | CDK5CDK5R1RAB9AMAPTNPC1 | |
| SCHEMBL21682845 | 0.81 | CDK5 (0.64) | CDK5CDK5R1RAB9ALMNAMAPK1 | |
| SCHEMBL5338197 | 0.80 | CDK5 (0.65) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5348176 | 0.78 | CDK5 (1.00) | CDK5CDK5R1RAB9ALMNANPC1 | |
| SCHEMBL5345256 | 0.77 | CDK5 (0.61) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5345431 | 0.76 | CDK5 (0.78) | CDK5CDK5R1LMNAMAPK1MAPT | |
| SCHEMBL5788420 | 0.75 | CDK5 (0.70) | CDK5CDK5R1RAB9AMAPK1NPC1 | |
| SCHEMBL5348977 | 0.75 | CDK5 (0.62) | CDK5CDK5R1LMNAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |