Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.43 |
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | STK4 | Q13043 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560319 | 0.92 | HSD17B10 (0.43) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL1981272 | 0.88 | KDR (0.51) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL14560302 | 0.88 | FGFR1 (0.42) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL14560321 | 0.86 | FGFR1 (0.41) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL6326961 | 0.82 | HSD17B10 (0.41) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL5831540 | 0.80 | SMN1; SMN2 (0.52) | NPSR1 | |
| SCHEMBL6740330 | 0.79 | FGFR1 (0.44) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL14560305 | 0.79 | HSD17B10 (0.38) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL14560303 | 0.78 | FGFR1 (0.38) | HSD17B10FGFR1KDRPDGFRBAURKA | |
| SCHEMBL14560304 | 0.78 | GPR17 (0.43) | HSD17B10GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |