Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.45 |
| ▸ | KDR | P35968 | 10/20 | 0.44 |
| ▸ | LCK | P06239 | 9/20 | 0.44 |
| ▸ | FYN | P06241 | 9/20 | 0.44 |
| ▸ | YES1 | P07947 | 9/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401598 | 0.92 | SRC (0.52) | SRCKDRLCKFYNYES1 | |
| SCHEMBL6696857 | 0.91 | SRC (0.51) | SRCKDRLCKFYNYES1 | |
| SCHEMBL5414923 | 0.81 | SRC (0.44) | SRCKDRLCKFYNYES1 | |
| SCHEMBL6606058 | 0.78 | SRC (0.50) | SRCKDRLCKFYNYES1 | |
| SCHEMBL5399026 | 0.78 | SRC (0.53) | SRCKDRLCKFYNYES1 | |
| SCHEMBL6615698 | 0.77 | SRC (0.44) | SRCKDRLCKFYNYES1 | |
| SCHEMBL6602200 | 0.77 | SRC (0.53) | SRCKDRLCKFYNYES1 | |
| SCHEMBL6612944 | 0.75 | SRC (0.54) | SRCKDRLCKFYNYES1 | |
| SCHEMBL5406462 | 0.74 | SRC (0.42) | SRCKDRLCKFYNYES1 | |
| SCHEMBL6615469 | 0.73 | SRC (0.56) | SRCKDRLCKFYNYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |