Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.54 |
| ▸ | CDK4 | P11802 | 17/20 | 0.53 |
| ▸ | PLK1 | P53350 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CDK7 | P50613 | 3/20 | 0.49 |
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4614057 | 0.82 | CDK2 (0.57) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2284139 | 0.82 | CDK2 (0.69) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2290008 | 0.82 | CDK2 (0.55) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2278842 | 0.81 | CDK2 (0.56) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2286557 | 0.81 | CDK2 (0.56) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2289382 | 0.79 | CDK2 (0.56) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2282084 | 0.78 | CDK4 (0.58) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2286813 | 0.77 | CDK2 (0.52) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL6157181 | 0.77 | CDK2 (0.76) | CDK2CDK4PLK1AURKACDK1 | |
| SCHEMBL2084100 | 0.74 | CDK2 (0.60) | CDK2CDK4PLK1AURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1760082-A1 | N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl)-N-phenylamines as anti-proliferative compounds | Cyclacel Limited (GB) | 2007-03-07 | — | — | EP | disclosed |