Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.66 |
| ▸ | CDC7 | O00311 | 7/20 | 0.58 |
| ▸ | CDK9 | P50750 | 5/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.58 |
| ▸ | PIM1 | P11309 | 5/20 | 0.58 |
| ▸ | PRKACA | P17612 | 5/20 | 0.58 |
| ▸ | GSK3B | P49841 | 5/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.58 |
| ▸ | CLK2 | P49760 | 4/20 | 0.58 |
| ▸ | CDK7 | P50613 | 4/20 | 0.58 |
| ▸ | PRKX | P51817 | 4/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.58 |
| ▸ | PAK4 | O96013 | 3/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.58 |
| ▸ | CDK8 | P49336 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604217 | 0.80 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1603523 | 0.78 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1604041 | 0.78 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1603903 | 0.78 | PDPK1 (0.60) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1604049 | 0.77 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1603553 | 0.77 | DYRK1A (0.72) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1604071 | 0.76 | PDPK1 (0.78) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1603476 | 0.75 | PDPK1 (0.74) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1603905 | 0.75 | PDPK1 (0.80) | PDPK1CDC7CDK9CDK5MAP4K4 | |
| SCHEMBL1456993 | 0.75 | PDPK1 (0.63) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420820-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | claimed |
| JP-2011526260-A | — | — | 2011-10-06 | — | — | JP | claimed |
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2011-09-08 | — | — | US | claimed |
| EP-2291375-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | Merck Patent GmbH (DE) | 2011-03-09 | — | — | EP | claimed |
| WO-2010000364-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-01-07 | — | — | WO | claimed |
| US-8420820-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-8420820-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-8420820-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2011-09-08 | — | — | US | disclosed |
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2011-09-08 | — | — | US | disclosed |
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2011-09-08 | — | — | US | disclosed |
| EP-2291375-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | Merck Patent GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |
| WO-2010000364-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-01-07 | — | — | WO | disclosed |
| WO-2010000364-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MKI67, CCNT1, CCNI | PDPK1 429/4885CDC7 581/4885CDK9 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.