Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.68 |
| ▸ | PDE1A | P54750 | 6/20 | 0.68 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.68 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.68 |
| ▸ | PDE6A | P16499 | 2/20 | 0.68 |
| ▸ | PDE2A | O00408 | 1/20 | 0.68 |
| ▸ | PDE6D | O43924 | 1/20 | 0.68 |
| ▸ | PDE9A | O76083 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | PDE6G | P18545 | 1/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | PDE6B | P35913 | 1/20 | 0.68 |
| ▸ | PDE6C | P51160 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973386 | 0.91 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL972506 | 0.91 | PDE5A (0.73) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL974182 | 0.90 | PDE5A (0.72) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL974583 | 0.87 | PDE5A (0.89) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL973387 | 0.86 | PDE5A (0.75) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL31347918 | 0.86 | PDE5A (0.90) | PDE5APDE1APDE1BPDE1CPDE4B | |
| Hydrochloric Acid SCHEMBL974259 | 0.86 | PDE5A (0.88) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL5606 | 0.85 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL8256126 | 0.85 | PDE5A (0.73) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL975193 | 0.85 | PDE5A (0.90) | PDE5APDE1APDE1BPDE1CPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295436-A1 | 2-Phenyl-subsitituted Imidazotriazinones as Phosphodiesterase V inhibitors | Bayer Schering Pharma AG (DE) | 2011-03-16 | — | — | EP | disclosed |
| EP-1733728-A2 | Use of 2-alkoxyphenyl substituted imidazotriazinones as inhibitors of phosphodiesterase | Bayer HealthCare AG (DE) | 2006-12-20 | — | — | EP | disclosed |
| EP-1174431-A2 | 2-Phenyl-substituited Imidazotriazinones as Phoshodiesterase Inhibitors | Bayer Aktiengesellschaft (DE) | 2002-01-23 | — | — | EP | disclosed |
| EP-1049695-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER AG (DE) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999024433-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-05-20 | — | — | WO | disclosed |