Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70520 | 0.73 | HRH3 (0.44) | SMN1; SMN2HRH3CHRM3KDM4EHSD11B1 | |
| SCHEMBL10241703 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2HRH3CHRM3KDM4EHSD11B1 | |
| SCHEMBL7903518 | 0.71 | HRH3 (0.43) | SMN1; SMN2HRH3CHRM3HSD11B1 | |
| SCHEMBL18773643 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2HRH3CHRM3KDM4EHSD11B1 | |
| SCHEMBL27880313 | 0.71 | HRH3 (0.43) | SMN1; SMN2HRH3CHRM3HSD11B1 | |
| SCHEMBL15387018 | 0.71 | HRH3 (0.43) | SMN1; SMN2HRH3CHRM3KDM4EHSD11B1 | |
| SCHEMBL15684438 | 0.71 | — | — | |
| SCHEMBL28784801 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2HRH3CHRM3KDM4EHSD11B1 | |
| SCHEMBL13520344 | 0.69 | SMN1; SMN2 (0.41) | SMN1; SMN2HRH3CHRM3KDM4EHSD11B1 | |
| SCHEMBL4695552 | 0.69 | SMN1; SMN2 (0.50) | SMN1; SMN2HRH3CHRM3HSD11B1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025009-A2 | INDENOISOQUINOLINONE ANALOGS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-03-01 | — | — | WO | disclosed |