Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | RAF1 | P04049 | 10/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | PAK3 | O75914 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13559580 | 0.92 | BRAF (0.76) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL2894143 | 0.89 | BRAF (0.76) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL13504266 | 0.87 | BRAF (0.71) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL13209869 | 0.87 | BRAF (0.78) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL12811799 | 0.87 | BRAF (0.72) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL2892205 | 0.86 | BRAF (0.72) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL13210398 | 0.85 | BRAF (0.69) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL2893190 | 0.85 | BRAF (0.73) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL2893957 | 0.84 | BRAF (0.69) | BRAFCYP3A4LCKRAF1KDR | |
| SCHEMBL2893885 | 0.84 | BRAF (0.71) | BRAFCYP3A4LCKRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027950-A1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION | NOVARTIS AG (CH) | 2007-03-08 | — | — | WO | disclosed |