Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 6/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119462 | 0.94 | CYP2C8 (0.74) | CYP2C8KCNH2CYP3A4NR1I2MAPK14 | |
| SCHEMBL143480 | 0.90 | CYP2C8 (0.77) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL141259 | 0.89 | CYP2C8 (0.72) | CYP2C8KCNH2CYP3A4NR1I2MAPK14 | |
| SCHEMBL142368 | 0.88 | CYP2C8 (0.78) | CYP2C8KCNH2CYP3A4NR1I2MAPK14 | |
| SCHEMBL143635 | 0.87 | CYP2C8 (0.72) | CYP2C8KCNH2CYP3A4NR1I2MAPK14 | |
| SCHEMBL2143297 | 0.87 | CYP2C8 (0.78) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL140781 | 0.87 | CYP2C8 (0.56) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL142465 | 0.87 | CYP2C8 (0.78) | CYP2C8KCNH2CYP3A4NR1I2MAPK14 | |
| SCHEMBL145304 | 0.86 | CYP2C8 (0.72) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL2138449 | 0.85 | CYP2C8 (0.78) | CYP2C8KCNH2CYP3A4NR1I2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354410-B2 | Compounds for the treatment of hepatitis C | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2013-01-15 | — | — | US | disclosed |
| US-20120059019-A1 | Compounds for the Treatment of Hepatitis C | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059019-A1 | Compounds for the Treatment of Hepatitis C | HAVCR2, HCCS, SLC10A1 | CYP2C8 85/4885KCNH2 3814/4885CYP3A4 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.