Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424934 | 0.81 | HSP90AA1 (0.68) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL14506500 | 0.76 | HSP90AA1 (0.57) | HSP90AA1TRAP1PIK3CAMTORRICTOR | |
| SCHEMBL3391504 | 0.75 | HSP90AA1 (0.54) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL3393039 | 0.74 | HSP90AA1 (0.54) | HSP90AA1TRAP1PIK3CAMTORRICTOR | |
| SCHEMBL14506471 | 0.71 | HSP90AA1 (0.41) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL14506499 | 0.69 | HSP90AA1 (0.42) | HSP90AA1PIK3CAMTORRICTORRPTOR | |
| SCHEMBL8129925 | 0.66 | PIK3CD (0.50) | PIK3CA | |
| SCHEMBL3393936 | 0.66 | HSP90AA1 (0.69) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL3396133 | 0.64 | HSP90AA1 (0.66) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL14568048 | 0.64 | HSP90AA1 (0.49) | HSP90AA1TRAP1HSP90AB1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035963-A2 | ANTI-TUMOR METHODS USING MULTI DRUG RESISTANCE INDEPENDENT SYNTHETIC HSP90 INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-03-29 | — | — | WO | disclosed |