SCHEMBL14567746

SCHEMBL14567746

CC(C)(C)c1[nH]cnc1/C=c1\[nH]c(=O)/c(=C/c2ccc(N)cc2)[nH]c1=O

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.79
CYP2C9 P11712 2/20 0.79
CYP2C19 P33261 2/20 0.79
RAF1 P04049 1/20 0.79
CDK1 P06493 1/20 0.79
CCNB1 P14635 1/20 0.79
TUBB4A P04350 2/20 0.59
TUBB P07437 2/20 0.59
TUBA3C P0DPH7 2/20 0.59
TUBA1B P68363 2/20 0.59
TUBA4A P68366 2/20 0.59
TUBB4B P68371 2/20 0.59
TUBB3 Q13509 2/20 0.59
TUBB2A Q13885 2/20 0.59
TUBB8 Q3ZCM7 2/20 0.59
TUBA3E Q6PEY2 2/20 0.59
TUBA1A Q71U36 2/20 0.59
TUBA1C Q9BQE3 2/20 0.59
TUBB6 Q9BUF5 2/20 0.59
TUBB2B Q9BVA1 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30743914 0.95 CYP1A2 (0.87) CYP1A2CYP2C9CYP2C19RAF1CDK1
SCHEMBL80052 0.90 CYP1A2 (0.79) CYP1A2CYP2C9CYP2C19RAF1CDK1
SCHEMBL79853 0.90 CYP1A2 (0.79) CYP1A2CYP2C9CYP2C19RAF1CDK1
SCHEMBL10207768 0.88 CYP1A2 (0.77) CYP1A2CYP2C9CYP2C19RAF1CDK1
SCHEMBL79693 0.88 CYP1A2 (0.77) CYP1A2CYP2C9CYP2C19RAF1CDK1
SCHEMBL79295 0.88 CYP1A2 (0.77) CYP1A2CYP2C9CYP2C19RAF1CDK1
Plinabulin SCHEMBL79095 0.88 CYP1A2 (1.00) CYP1A2CYP2C9CYP2C19RAF1CDK1
Plinabulin SCHEMBL21050030 0.88 CYP1A2 (1.00) CYP1A2CYP2C9CYP2C19RAF1CDK1
Plinabulin SCHEMBL29033820 0.88 CYP1A2 (1.00) CYP1A2CYP2C9CYP2C19RAF1CDK1
Plinabulin SCHEMBL29216847 0.88 CYP1A2 (1.00) CYP1A2CYP2C9CYP2C19RAF1CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007035841-A1 ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THERAPEUTIC USE NEREUS PHARMACEUTICALS, INC. (US) 2007-03-29 WO disclosed