SCHEMBL14567906

SCHEMBL14567906

COc1nc(Cn2nnc3c(Cl)nc(N)nc32)c(Cl)c(OC)c1OC

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 13/20 0.43
HSP90AB1 P08238 12/20 0.43
TRAP1 Q12931 2/20 0.40
HSP90B1 P14625 1/20 0.40
PDE8B O95263 2/20 0.38
ADORA3 P0DMS8 4/20 0.35
ADORA2A P29274 4/20 0.35
ADORA2B P29275 4/20 0.35
ADORA1 P30542 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14567904 0.89 HSP90AA1 (0.44) HSP90AA1HSP90AB1TRAP1HSP90B1PDE8B
SCHEMBL14567910 0.89 HSP90AA1 (0.37) HSP90AA1HSP90AB1TRAP1HSP90B1PDE8B
SCHEMBL3396046 0.83 HSP90AB1 (0.46) HSP90AA1HSP90AB1TRAP1HSP90B1PDE8B
SCHEMBL14568330 0.80 HSP90AA1 (0.64) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL14438216 0.78 HSP90AB1 (0.67) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL14506465 0.78 HSP90AA1 (0.65) HSP90AA1HSP90AB1TRAP1HSP90B1ADORA2A
SCHEMBL14506471 0.78 HSP90AA1 (0.41) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL14567899 0.77 HSP90AA1 (0.48) HSP90AA1HSP90AB1TRAP1HSP90B1ADORA3
SCHEMBL14506524 0.77 HSP90AA1 (0.52) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL3392377 0.77 HSP90AB1 (0.68) HSP90AA1HSP90AB1TRAP1HSP90B1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007035963-A2 ANTI-TUMOR METHODS USING MULTI DRUG RESISTANCE INDEPENDENT SYNTHETIC HSP90 INHIBITORS CONFORMA THERAPEUTICS CORPORATION (US) 2007-03-29 WO disclosed