SCHEMBL1456871

SCHEMBL1456871

CCC(Cl)OCc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.44
IDO1 P14902 1/20 0.41
TP53 P04637 1/20 0.41
SLC1A3 P43003 2/20 0.41
SLC1A2 P43004 2/20 0.41
SLC1A1 P43005 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41
AGXT P21549 1/20 0.40
ALDH1A1 P00352 2/20 0.39
SLC6A2 P23975 2/20 0.39
SLC6A4 P31645 2/20 0.39
SLC6A3 Q01959 2/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNA4 P43681 1/20 0.39
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8114209 0.84 PPARG (0.42) TSHRIDO1TP53SLC1A3SLC1A2
SCHEMBL8114978 0.81 CETP (0.41) TSHRIDO1SLC1A3SLC1A2SLC1A1
SCHEMBL10967299 0.81 TSHR (0.43) TSHRIDO1TP53SLC1A3SLC1A2
SCHEMBL14667806 0.81 TSHR (0.46) TSHRIDO1SLC1A3SLC1A2SLC1A1
SCHEMBL6731649 0.80 CA1 (0.39) IDO1TP53ALDH1A1SLC6A2SLC6A4
SCHEMBL10965779 0.79 TSHR (0.44) TSHRIDO1SLC1A3SLC1A2SLC1A1
SCHEMBL14998980 0.79 TSHR (0.40) TSHRIDO1SLC1A3SLC1A2SLC1A1
SCHEMBL9915100 0.78 TSHR (0.48) TSHRIDO1TP53SLC1A3SLC1A2
SCHEMBL3079998 0.78 TSHR (0.48) TSHRIDO1TP53SLC1A3SLC1A2
SCHEMBL5503634 0.78 TSHR (0.48) TSHRIDO1SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117447378-A Preparation method of silodosin chiral intermediate 斯坦德药典标准物质研发(湖北)有限公司 2024-01-26 CN claimed
CN-117447378-A Preparation method of silodosin chiral intermediate 斯坦德药典标准物质研发(湖北)有限公司 2024-01-26 CN disclosed
EP-1833821-B1 SULFAMIDES AS ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES ACTELION PHARMACEUTICALS LTD (CH) 2011-03-30 EP disclosed
US-6682869-B2 IN POLYMER SHIN-ETU CHEMICAL CO., LTD. (JP) 2004-01-27 US disclosed
US-20010038971-A1 Chemical amplification, positive resist compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 2001-11-08 US disclosed
EP-1056744-A1 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES Aventis Pharmaceuticals Inc. (US) 2000-12-06 EP disclosed
WO-1999043675-A1 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES AVENTIS PHARMACEUTICALS INC. (US) 1999-09-02 WO disclosed
US-4866206-A INHIBITORS OF ORNITHINE DECARBOXYLASE MERRELL DOW FRANCE ET CIE (FR) 1989-09-12 US disclosed