Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518148 | 0.81 | ADORA2A (0.66) | ADORA2AADORA1PRKDC | |
| SCHEMBL14569112 | 0.80 | ADORA2A (0.54) | ADORA2AADORA1PRKDCEGFR | |
| SCHEMBL12371722 | 0.78 | GSK3B (0.42) | ADORA2AADORA1JAK1JAK2JAK3 | |
| SCHEMBL4527516 | 0.77 | ADORA2A (0.89) | ADORA2AADORA1 | |
| SCHEMBL4507899 | 0.75 | ADORA2A (0.53) | ADORA2AADORA1 | |
| SCHEMBL14569129 | 0.75 | ADORA2A (0.44) | ADORA2AADORA1 | |
| SCHEMBL4512221 | 0.75 | ADORA2A (0.63) | ADORA2AADORA1EGFR | |
| SCHEMBL12371704 | 0.75 | KDM1A (0.44) | ADORA2AADORA1JAK1JAK2CACNA2D1 | |
| SCHEMBL4510903 | 0.74 | CYP1A2 (0.54) | ADORA2A | |
| SCHEMBL4507905 | 0.73 | ADORA2A (0.46) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035873-A1 | PURINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-03-29 | — | — | WO | disclosed |