Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347201 | 1.00 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1CPT1A | |
| SCHEMBL14558502 | 0.86 | CDK5 (0.56) | CDK5CDK5R1DYRK1AROCK1ACKR3 | |
| SCHEMBL5338445 | 0.86 | CDK5 (0.56) | CDK5CDK5R1DYRK1AROCK1ACKR3 | |
| SCHEMBL14558880 | 0.86 | CDK5 (0.56) | CDK5CDK5R1DYRK1AROCK1ACKR3 | |
| SCHEMBL5352022 | 0.86 | CDK5 (0.50) | CDK5CDK5R1DYRK1AROCK1CPT1A | |
| SCHEMBL5341555 | 0.86 | CDK5 (0.50) | CDK5CDK5R1DYRK1AROCK1ACKR3 | |
| SCHEMBL5348206 | 0.85 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1ALOX5AP | |
| SCHEMBL14558453 | 0.84 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1ALOX5AP | |
| SCHEMBL5348501 | 0.84 | CDK5 (0.55) | CDK5CDK5R1DYRK1AROCK1CPT1A | |
| SCHEMBL5344526 | 0.82 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |