Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870474 | 0.74 | HRH1 (0.53) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL12065131 | 0.70 | HRH1 (0.51) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL13870569 | 0.68 | HRH1 (0.43) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL6418027 | 0.65 | HRH1 (0.54) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL6994690 | 0.64 | HRH1 (0.71) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL6178576 | 0.63 | HRH1 (0.73) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL6179271 | 0.63 | HRH1 (0.67) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| SCHEMBL6337294 | 0.63 | HRH1 (0.57) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| Desloratadine SCHEMBL29390260 | 0.62 | HRH1 (1.00) | HTR2BHTR2AHTR2CHRH1HTR1A | |
| Desloratadine SCHEMBL29371361 | 0.62 | HRH1 (1.00) | HTR2BHTR2AHTR2CHRH1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |