Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 17/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5412277 | 0.90 | TTK (0.57) | TTKFLT3 | |
| SCHEMBL5412038 | 0.89 | TTK (0.72) | TTKFLT3 | |
| SCHEMBL5411929 | 0.85 | IKBKB (0.49) | TTKFLT3 | |
| SCHEMBL5404865 | 0.84 | FLT3 (0.56) | TTKFLT3 | |
| SCHEMBL5411618 | 0.84 | FLT3 (0.56) | TTKFLT3 | |
| SCHEMBL5403440 | 0.84 | FLT3 (0.59) | TTKFLT3 | |
| SCHEMBL9938190 | 0.83 | TTK (0.82) | TTK | |
| SCHEMBL5418638 | 0.83 | TTK (0.64) | TTK | |
| SCHEMBL5411354 | 0.82 | TTK (0.61) | TTKFLT3 | |
| SCHEMBL5401420 | 0.81 | FLT3 (0.56) | TTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |