Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 2/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403916 | 0.82 | FLT3 (0.51) | FLT3BTKTNK2 | |
| SCHEMBL5394301 | 0.80 | FLT3 (0.49) | FLT3ADORA3BRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ALDH1A1 | |
| SCHEMBL5403440 | 0.75 | FLT3 (0.59) | FLT3ADORA3 | |
| SCHEMBL5404865 | 0.73 | FLT3 (0.56) | FLT3 | |
| SCHEMBL5399698 | 0.71 | FLT3 (0.54) | FLT3ADORA3IKBKBCHUK | |
| SCHEMBL5618679 | 0.70 | FLT3 (0.64) | FLT3ADORA3IKBKB | |
| SCHEMBL5403945 | 0.70 | TTK (0.48) | FLT3 | |
| SCHEMBL5411370 | 0.70 | FLT3 (0.53) | FLT3IKBKBCHUK | |
| SCHEMBL5405124 | 0.70 | FLT3 (0.52) | FLT3IKBKB | |
| SCHEMBL5396717 | 0.69 | FLT3 (0.55) | FLT3ADORA3IKBKBCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |