Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 14/20 | 0.46 |
| ▸ | KDR | P35968 | 14/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405188 | 0.86 | CHRNA7 (0.47) | FGFR3KDRBRAFTTK | |
| SCHEMBL5418767 | 0.84 | MEN1 (0.47) | FGFR3KDRBRAFTTK | |
| SCHEMBL5396618 | 0.82 | SMN1; SMN2 (0.48) | FGFR3KDRBRAF | |
| SCHEMBL5404519 | 0.80 | EGFR (0.48) | FGFR3KDRBRAF | |
| SCHEMBL5416134 | 0.78 | FYN (0.54) | BRAFTTK | |
| SCHEMBL5618376 | 0.77 | JAK3 (0.51) | KDRBRAFTTK | |
| SCHEMBL5405261 | 0.76 | TTK (0.44) | FGFR3KDRBRAFTTK | |
| SCHEMBL5618277 | 0.76 | JAK3 (0.45) | FGFR3KDRBRAFTTK | |
| SCHEMBL5394669 | 0.75 | TTK (0.54) | KDRTTK | |
| SCHEMBL14593807 | 0.74 | TTK (0.40) | FGFR3KDRBRAFTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |