Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 12/20 | 0.43 |
| ▸ | KDR | P35968 | 10/20 | 0.43 |
| ▸ | TTK | P33981 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618106 | 0.83 | TTK (0.56) | TTKFLT3 | |
| SCHEMBL5416134 | 0.82 | FYN (0.54) | TTKBRAFFLT3 | |
| SCHEMBL5618376 | 0.80 | JAK3 (0.51) | KDRTTKBRAF | |
| SCHEMBL5618973 | 0.79 | TTK (0.47) | FGFR3KDRTTKBRAFFLT3 | |
| SCHEMBL5618489 | 0.79 | EGFR (0.46) | FGFR3KDRTTKBRAF | |
| SCHEMBL5618369 | 0.78 | JAK3 (0.54) | FLT3 | |
| SCHEMBL5618277 | 0.77 | JAK3 (0.45) | FGFR3KDRTTKBRAF | |
| SCHEMBL3466505 | 0.76 | FYN (0.58) | FGFR3KDRTTKBRAF | |
| SCHEMBL5396387 | 0.75 | FYN (0.48) | KDRTTKFLT3 | |
| SCHEMBL5420238 | 0.75 | FLT3 (0.52) | TTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |