SCHEMBL14575871

SCHEMBL14575871

CN(CC=CC(=O)O)C1CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.46
HTR2C P28335 3/20 0.46
HTR2B P41595 3/20 0.46
SIGMAR1 Q99720 3/20 0.46
KDM4E B2RXH2 1/20 0.40
LSS P48449 3/20 0.40
TSHR P16473 3/20 0.37
GABRR1 P24046 2/20 0.37
GABRR2 P28476 2/20 0.37
BLM P54132 2/20 0.37
GABRR3 A8MPY1 1/20 0.37
LMNA P02545 1/20 0.37
APEX1 P27695 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
DRD2 P14416 1/20 0.34
POLB P06746 1/20 0.31
TP53 P04637 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31
EGLN3 Q9H6Z9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14575869 1.00 HTR2A (0.46) HTR2AHTR2CHTR2BSIGMAR1KDM4E
Hydrochloric Acid SCHEMBL15136221 0.98 HTR2A (0.45) HTR2AHTR2CHTR2BSIGMAR1KDM4E
Hydrochloric Acid SCHEMBL15136222 0.98 HTR2A (0.45) HTR2AHTR2CHTR2BSIGMAR1KDM4E
SCHEMBL14575792 0.94 KDM4E (0.46) HTR2AHTR2CHTR2BSIGMAR1KDM4E
SCHEMBL14575794 0.94 KDM4E (0.46) HTR2AHTR2CHTR2BSIGMAR1KDM4E
Hydrochloric Acid SCHEMBL14576547 0.92 KDM4E (0.45) HTR2AHTR2CHTR2BSIGMAR1KDM4E
Hydrochloric Acid SCHEMBL14576545 0.92 KDM4E (0.45) HTR2AHTR2CHTR2BSIGMAR1KDM4E
SCHEMBL15171151 0.84 LSS (0.40) HTR2AHTR2CHTR2BSIGMAR1KDM4E
SCHEMBL14617850 0.82 HTR2A (0.39) HTR2AHTR2CHTR2BSIGMAR1KDM4E
SCHEMBL30719715 0.82 LSS (0.39) HTR2AHTR2CHTR2BSIGMAR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240124467-A1 FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION BIOMEA FUSION, INC. 2024-04-18 US disclosed
EP-4263542-A1 FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION Biomea Fusion, Inc. (US) 2023-10-25 EP disclosed
WO-2022133064-A1 FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION BIOMEA FUSION, INC. (US) 2022-06-23 WO disclosed
US-10793576-B2 Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD. (CN) 2020-10-06 US disclosed
US-20200079754-A1 INHIBITORS OF BRUTONS TYROSINE KINASE PHARMACYCLICS LLC (US) 2020-03-12 US disclosed
US-20190315758-A1 COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD. (CN) 2019-10-17 US disclosed
US-20190144451-A1 PURINONE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS LLC 2019-05-16 US disclosed
US-20190100505-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS LLC (US) 2019-04-04 US disclosed
US-20180037583-A1 PURINONE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS LLC (US) 2018-02-08 US disclosed
US-20180030027-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS LLC (US) 2018-02-01 US disclosed
WO-2015084998-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2015-06-11 WO disclosed
WO-2015002894-A1 PURINONE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS, INC. (US) 2015-01-08 WO disclosed
WO-2014078578-A1 PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS, INC. (US) 2014-05-22 WO disclosed
US-20140142126-A1 PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS, INC. (US) 2014-05-22 US disclosed
EP-2731612-A2 INHIBITORS OF BRUTON'S TYROSINE KINASE Pharmacyclics, Inc. (US) 2014-05-21 EP disclosed
US-20130172314-A1 PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS, INC. (US) 2013-07-04 US disclosed
WO-2013102059-A1 PYRAZOLO [3, 4-D] PYRIMIDINE AND PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS PHARMACYCLICS, INC. (US) 2013-07-04 WO disclosed
US-8377946-B1 Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors PHARMACYCLICS, INC. (US) 2013-02-19 US disclosed
US-20130018032-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2013-01-17 US disclosed
WO-2013010136-A2 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2013-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180037583-A1 PURINONE COMPOUNDS AS KINASE INHIBITORS BTK, LCK, BCL9 HTR2A 1642/4885HTR2C 1616/4885HTR2B 1052/4885
US-20190315758-A1 COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF BTK, SYK, LYN HTR2A 4489/4885HTR2C 4032/4885HTR2B 3788/4885
US-20190144451-A1 PURINONE COMPOUNDS AS KINASE INHIBITORS BTK, LCK, BCL9 HTR2A 1642/4885HTR2C 1616/4885HTR2B 1052/4885
US-20130172314-A1 PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS BTK, LCK, LYN HTR2A 3635/4885HTR2C 2751/4885HTR2B 3099/4885
US-20240124467-A1 FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION MLLT1, MEN1, MLLT3 HTR2A 4344/4885HTR2C 4352/4885HTR2B 3802/4885
US-20130018032-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 HTR2A 4474/4885HTR2C 3968/4885HTR2B 4154/4885
US-20180030027-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, LYN, LCK HTR2A 4019/4885HTR2C 3734/4885HTR2B 3298/4885
US-20140142126-A1 PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS BTK, LCK, LYN HTR2A 4363/4885HTR2C 4102/4885HTR2B 3734/4885
US-20200079754-A1 INHIBITORS OF BRUTONS TYROSINE KINASE BTK, LYN, LCK HTR2A 4000/4885HTR2C 3942/4885HTR2B 3559/4885
US-10793576-B2 Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof BTK, SYK, LYN HTR2A 4489/4885HTR2C 4032/4885HTR2B 3788/4885
US-20190100505-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, LYN, LCK HTR2A 3909/4885HTR2C 3688/4885HTR2B 3267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.