Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13000328 | 0.94 | NOTUM (0.50) | NOTUMAXLCSNK1DMERTKBCHE | |
| SCHEMBL14580769 | 0.94 | NOTUM (0.54) | NOTUMAXLCSNK1DMERTKSLC18A3 | |
| SCHEMBL14580788 | 0.91 | NOTUM (0.52) | NOTUMAXLCSNK1DMERTKSLC18A3 | |
| SCHEMBL13000600 | 0.91 | NOTUM (0.52) | NOTUMALDH1A1KMT2A | |
| SCHEMBL12999998 | 0.89 | NOTUM (0.52) | NOTUMAXLCSNK1DMERTKSLC18A3 | |
| SCHEMBL14580751 | 0.89 | NOTUM (0.54) | NOTUMAXLCSNK1DMERTKSLC18A3 | |
| SCHEMBL14580839 | 0.88 | NOTUM (0.49) | NOTUMAXLCSNK1DMERTKSLC18A3 | |
| SCHEMBL14580764 | 0.87 | NOTUM (0.52) | NOTUMAXLCSNK1DMERTKSLC18A3 | |
| SCHEMBL12084247 | 0.87 | NOTUM (0.54) | NOTUMAXLCSNK1DMERTKALDH1A1 | |
| SCHEMBL14580791 | 0.86 | NOTUM (0.49) | NOTUMAXLCSNK1DMERTKSLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043023-A1 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043023-A1 | Modulators of muscarinic receptors | CHRM3, CHRM5, CHRM2 | NOTUM 1391/4885AXL 2493/4885CSNK1D 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.