Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.46 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14587260 | 1.00 | POLB (0.51) | POLBHPGDHSD11B1HSD11B2LMNA | |
| Trifluoroacetic Acid SCHEMBL5639539 | 0.89 | HPGD (0.44) | POLBHPGDHSD11B1HSD11B2LMNA | |
| Trifluoroacetic Acid SCHEMBL5639463 | 0.89 | HPGD (0.44) | POLBHPGDHSD11B1HSD11B2LMNA | |
| SCHEMBL4520708 | 0.84 | POLB (0.47) | POLBHPGDHSD11B1HSD11B2LMNA | |
| SCHEMBL14587255 | 0.84 | HPGD (0.54) | POLBHPGDHSD11B1HSD11B2LMNA | |
| SCHEMBL14587259 | 0.84 | HPGD (0.54) | POLBHPGDHSD11B1HSD11B2LMNA | |
| SCHEMBL5636522 | 0.82 | HPGD (0.55) | POLBHPGDHSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL14587302 | 0.82 | HPGD (0.55) | POLBHPGDHSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL4540695 | 0.81 | HPGD (0.50) | POLBHPGDHSD11B1HSD11B2LMNA | |
| SCHEMBL4536414 | 0.80 | HPGD (0.53) | POLBHPGDHSD11B1HSD11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |