Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537551 | 1.00 | POLB (0.44) | POLBHPGDALOX5APALDH1A1KDM4E | |
| Trifluoroacetic Acid SCHEMBL5639024 | 0.90 | ALOX5AP (0.41) | POLBHPGDALOX5APALDH1A1KDM4E | |
| Trifluoroacetic Acid SCHEMBL5639310 | 0.90 | ALOX5AP (0.41) | POLBHPGDALOX5APALDH1A1KDM4E | |
| SCHEMBL14587255 | 0.83 | HPGD (0.54) | POLBHPGDALDH1A1HTTLMNA | |
| SCHEMBL14587259 | 0.83 | HPGD (0.54) | POLBHPGDALDH1A1HTTLMNA | |
| Trifluoroacetic Acid SCHEMBL5637557 | 0.76 | HPGD (0.47) | POLBHPGDALDH1A1HTTLMNA | |
| Trifluoroacetic Acid SCHEMBL5639104 | 0.76 | HPGD (0.47) | POLBHPGDALDH1A1HTTLMNA | |
| SCHEMBL11914610 | 0.74 | POLB (0.58) | POLBHPGDALDH1A1KDM4EHTT | |
| SCHEMBL22484889 | 0.74 | POLB (0.58) | POLBHPGDALDH1A1KDM4EHTT | |
| SCHEMBL22485313 | 0.74 | POLB (0.58) | POLBHPGDALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |