Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.64 |
| ▸ | CHUK | O15111 | 10/20 | 0.64 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657736 | 0.91 | IKBKB (0.65) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589254 | 0.90 | IKBKB (0.64) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589202 | 0.90 | IKBKB (0.64) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589201 | 0.89 | IKBKB (0.63) | IKBKBCHUK | |
| SCHEMBL14589240 | 0.88 | IKBKB (0.59) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589255 | 0.88 | IKBKB (0.62) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589238 | 0.88 | IKBKB (0.62) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589223 | 0.86 | IKBKB (0.60) | IKBKBCHUK | |
| SCHEMBL14589226 | 0.84 | IKBKB (0.63) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589197 | 0.84 | IKBKB (0.59) | IKBKBCHUKCDK2BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176214-B2 | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-13 | — | — | US | disclosed |