Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.77 |
| ▸ | HPGD | P15428 | 6/20 | 0.77 |
| ▸ | TSHR | P16473 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 8/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195816 | 0.86 | SMN1; SMN2 (0.79) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL11674120 | 0.86 | SMN1; SMN2 (0.89) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL11840510 | 0.85 | NPC1 (0.93) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL27477472 | 0.84 | SMN1; SMN2 (0.77) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL13882293 | 0.84 | SMN1; SMN2 (0.85) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL12634931 | 0.83 | NPC1 (0.83) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL16675211 | 0.83 | SMN1; SMN2 (0.82) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL6311375 | 0.82 | CYP2A6 (0.60) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL6984735 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL19131306 | 0.81 | NPC1 (0.86) | SMN1; SMN2HPGDTSHRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | FINK CYNTHIA A | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | BRAF, RAF1, NRAS | SMN1; SMN2 4098/4885HPGD 1498/4885TSHR 2713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.