SCHEMBL14600712

SCHEMBL14600712

CCc1nn(-c2cccnc2C)c(Nc2ccc(C3CC3)cc2C(=O)O)c1-c1ccncc1

nearest known ligand 0.50

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 12/20 0.50
DHODH Q02127 8/20 0.44
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14600262 0.92 ADORA1 (0.49) ADORA1DHODHADORA3
SCHEMBL14600263 0.89 ADORA1 (0.49) ADORA1DHODHADORA3
SCHEMBL14600711 0.88 DHODH (0.49) ADORA1DHODHADORA3
SCHEMBL14600260 0.88 DHODH (0.46) ADORA1DHODH
SCHEMBL14600713 0.87 DHODH (0.44) ADORA1DHODHADORA3
SCHEMBL4666620 0.83 ADORA1 (0.50) ADORA1ADORA3
SCHEMBL14600715 0.80 DHODH (0.45) ADORA1DHODH
SCHEMBL14600253 0.75 DHODH (0.46) ADORA1DHODH
SCHEMBL4666643 0.75 ADORA1 (0.49) ADORA1DHODHADORA3
SCHEMBL14600658 0.75 ADORA1 (0.43) ADORA1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007027842-A1 ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES BAYER HEALTHCARE LLC (US) 2007-03-08 WO disclosed