Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.53 |
| ▸ | RAF1 | P04049 | 9/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | TEK | Q02763 | 3/20 | 0.40 |
| ▸ | STK25 | O00506 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | PAK3 | O75914 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14601482 | 0.87 | RAF1 (0.44) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL1435429 | 0.85 | BRAF (0.72) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL14565814 | 0.81 | BRAF (0.49) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL4376917 | 0.78 | BRAF (0.59) | BRAFRAF1KDRTEKTNNI3K | |
| SCHEMBL1435188 | 0.77 | BRAF (0.72) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL3021926 | 0.76 | BRAF (0.87) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2891766 | 0.75 | BRAF (0.76) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL2893468 | 0.74 | BRAF (0.73) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL1435292 | 0.74 | BRAF (0.73) | BRAFRAF1CYP3A4KDRLCK | |
| SCHEMBL2890045 | 0.74 | BRAF (0.75) | BRAFRAF1CYP3A4KDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030377-A1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-03-15 | — | — | WO | disclosed |