Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.81 |
| ▸ | RAF1 | P04049 | 8/20 | 0.69 |
| ▸ | LCK | P06239 | 4/20 | 0.69 |
| ▸ | KDR | P35968 | 4/20 | 0.69 |
| ▸ | FYN | P06241 | 3/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.69 |
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | FLT1 | P17948 | 3/20 | 0.69 |
| ▸ | FLT4 | P35916 | 3/20 | 0.69 |
| ▸ | STK25 | O00506 | 1/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.69 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | PAK3 | O75914 | 1/20 | 0.69 |
| ▸ | STK10 | O94804 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435333 | 0.95 | BRAF (0.81) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435438 | 0.90 | BRAF (1.00) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL13451258 | 0.89 | BRAF (0.83) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435526 | 0.88 | BRAF (1.00) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435125 | 0.87 | BRAF (0.80) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435273 | 0.85 | BRAF (0.77) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435358 | 0.85 | BRAF (0.88) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435386 | 0.85 | BRAF (0.76) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL3508319 | 0.84 | BRAF (0.76) | BRAFCYP3A4RAF1LCKKDR | |
| SCHEMBL1435499 | 0.83 | BRAF (0.79) | BRAFCYP3A4RAF1LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030377-A1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-03-15 | — | — | WO | disclosed |