Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14604142 | 0.90 | MAPK8 (0.53) | MAPK8ALDH1A1KDM4ETSHRMEN1 | |
| SCHEMBL14604214 | 0.86 | MAPK8 (0.51) | MAPK8ALDH1A1MEN1KMT2A | |
| SCHEMBL14604171 | 0.85 | MAPK8 (0.53) | MAPK8MAPTALDH1A1USP2TSHR | |
| SCHEMBL14603845 | 0.85 | MAPK8 (0.50) | MAPK8 | |
| SCHEMBL14604205 | 0.85 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL14603998 | 0.85 | MAPK8 (0.53) | MAPK8 | |
| SCHEMBL14604394 | 0.84 | MAPK8 (0.51) | MAPK8KMT2A | |
| SCHEMBL14604167 | 0.83 | MAPK8 (0.52) | MAPK8MEN1KMT2A | |
| SCHEMBL14604008 | 0.80 | MAPK8 (0.48) | MAPK8 | |
| SCHEMBL14604039 | 0.80 | MAPK8 (0.51) | MAPK8MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731932-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| WO-2013007676-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |