Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 12/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14604163 | 0.85 | MAPK8 (0.58) | MAPK8 | |
| SCHEMBL14604023 | 0.82 | MAPK8 (0.53) | MAPK8NPC1RAB9A | |
| SCHEMBL14604348 | 0.77 | MAPK8 (0.61) | MAPK8 | |
| SCHEMBL14604228 | 0.76 | MAPK8 (0.54) | MAPK8 | |
| SCHEMBL14604334 | 0.75 | GRIN1 (0.57) | MAPK8MEN1KMT2A | |
| SCHEMBL14576222 | 0.75 | MAPK8 (1.00) | MAPK8 | |
| SCHEMBL14604229 | 0.74 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL14604008 | 0.74 | MAPK8 (0.48) | MAPK8 | |
| SCHEMBL14604063 | 0.74 | MAPK8 (0.56) | MAPK8 | |
| SCHEMBL14604343 | 0.74 | MAPK8 (0.55) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731932-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| WO-2013007676-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |