Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.70 |
| ▸ | JAK2 | O60674 | 9/20 | 0.70 |
| ▸ | JAK3 | P52333 | 3/20 | 0.66 |
| ▸ | TYK2 | P29597 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2291267 | 1.00 | JAK1 (0.70) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL12424593 | 0.92 | JAK1 (0.73) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL14605230 | 0.92 | JAK1 (0.73) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL2296189 | 0.88 | JAK1 (0.77) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL14999954 | 0.88 | JAK1 (0.80) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL14605165 | 0.88 | JAK1 (0.69) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2291263 | 0.88 | JAK1 (0.69) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL14999683 | 0.85 | JAK1 (0.71) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL14644168 | 0.83 | JAK1 (0.67) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12385447 | 0.83 | JAK1 (1.00) | JAK1JAK2JAK3TYK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013007765-A1 | FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | claimed |
| WO-2013007765-A1 | FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |