Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 4/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14606042 | 0.79 | LCK (0.47) | LCKITKAURKBPARP1HDAC1 | |
| SCHEMBL14605899 | 0.76 | AURKB (0.54) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606097 | 0.76 | LCK (0.48) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605947 | 0.76 | AURKB (0.54) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605961 | 0.75 | LCK (0.63) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605951 | 0.75 | LCK (0.75) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606069 | 0.74 | AURKB (0.46) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605960 | 0.73 | LCK (0.50) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606098 | 0.71 | AURKB (0.52) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL31471834 | 0.71 | PAK4 (0.56) | AURKBPARP1PAK4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |